Publications

2020:

• Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, S., Zhang, C., Li. W., Dong, Y*., Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis, Nature Nanotechnology, (2020).

2019:

• Li, B*., Niu, Y*., Ji, W*., Dong, Y*., Strategies for the CRISPR-based therapeutics, Trends in Pharmacological Sciences, (2019).

• Zhao, W., Hou, X., Vick, O.G., Dong, Y*.,RNA delivery biomaterials for the treatment of genetic and rare diseases, Biomaterials, (2019). PMID: 31255978

 

• Dong, Y., Siegwart, D. J., Anderson, D.G., Strategies, design, and chemistry in siRNA delivery systems, Advanced drug delivery reviews, (2019). PMID: 31102606

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• Zhang, Y., Zhang, X., Zeng, C., Li, B., Zhang, C., Li, W., Hou, X., Dong Y*. Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR), Bioorganic & medicinal chemistry, 27(11): 2187-2191 (2019).

 

• Zhang, C., Zhao, W., Bian, C., Hou, X.,  Deng, B., McComb, D. W., Chen, X., Dong, Y*., Antibiotic-derived lipid nanoparticles to treat intracellular Staphylococcus aureus, ACS Appl. Bio Mater., 2(3): 1270-1277 (2019).

 

• Zhang, C., Zhang, X., Zhao, W., Zeng, C., Li, W., Li, B., Luo, X., Li, J., Jiang, J., Deng, B., McComb, D. W., Dong, Y*., Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer, Nano Research, 12(4):855-861 (2019).

2018:

• Zhang, X., Zhang, C., Yang, X., Hou, X., Zhao, W., Benson, D., Yu, J., Dong, Y*., Design, synthesis and evaluation of anti-CD38 antibody drug conjugate based on Daratumumab and Maytansinoid, Bioorganic & Medicinal Chemistry, 27(3):479-482 (2018). PMID: 30594452

   

 

• Li, B., Zeng, C., Li, W., Zhang, X., Luo, X., Zhao, W., Zhang, C., Dong, Y.*, Synthetic oligonucleotides inhibit CRISPR-Cpf1- mediated genome editing, Cell Reports, 25(12):3262-3272 (2018). PMID: 30566855

   

 

• Zhang, X., Zhao, W., Li, B., Li, W., Zhang, C., Hou, X., Jiang, J., Dong, Y.*, Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice, Chemical Science, 9(43):8207-8212 (2018). PMID: 30542568 (HOT Chemical Science articles for September)

 

• Zhao, W., Zhang, C., Li, B., Zhang, X., Luo, X., Zeng, C.,Li, W., Gao, M., Dong, Y.*, Lipid polymer hybrid nanomaterials for mRNA delivery, Cellular and Molecular Bioengineering, 11(5):397-406 (2018). PMID: 30555598

   

• Luo, X., Zhao, W., Li, B., Zhang, C., Bratasz, A., Deng, B., McComb, D. W., Dong, Y.*, Co-delivery of mRNA and SPIONs through amino-ester nanomaterials, Nano Research, 11(10):5596-5603 (2018).

 

 

• Li, B., Zhang, X., Dong, Y.*, Nanoscale platforms for messenger RNA delivery, Wiley Interdiscip Rev Nanomed Nanobiotechnol, e1530. PMID: 29726120

 

• Li, B., Zeng, C., Dong, Y.*, Design and assessment of engineered CRISPR– Cpf1 and its use for genome editing, Nature Protocols, 13(5):899–914 (2018).  PMID: 28840077

 

2017:

• Guo, S., Li, H., Ma, M., Fu, J., Dong, Y.*, Guo, P*., Size, shape, and sequence-dependent immunogenicity of RNA nanoparticles, Molecular Therapy: Nucleic Acids, 9:399-408 (2017). PMID: 5701797

 

 

• Zhang, X., Chen, X., Zhao, W., Zeng, C., Luo, X., Li, W., Li, B., Jiang, J., Dong, Y.,* GlcNAc conjugated atorvastatin with enhanced water solubility and cellular internalization, Bioconjugate Chem, 28(8):2109-2113 (2017). PMID: 28745862

 

 

• Zhang, X.,1 Li, B.,1 Luo, X.,1 Zhao, W., Jiang, J., Zhang, C., Gao, M., Chen, X., Dong, Y.,* Biodegradable amino-ester nanomaterials for Cas9 mRNA delivery in vitro and in vivo, ACS Appl. Mater. Interfaces, 9(30):25481-25487 (2017). PMID: 28685575

 

 

• Li, B., Zhao, W., Luo, X., Zhang, X., Li, C., Zeng, C., Dong, Y.,* Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency, Nature Biomedical Engineering, 1(5): (2017). PMID: 28840077
   

 

 

• Jiang, C.,1 Mei, M.,1 Li, B.,1 Zhu, X.,1 Zu, W., Tian, Y., Wang, Q., Guo, Y., Dong, Y.,* Tan, X.* A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo, Cell Research, 27(3):440-443 (2017). PMID: 28117345  

 

 

• Luo, X., Li, B., Zhang, X., Zhao, W., Bratasz, A., Deng, B., McComb, D. W., Dong, Y.* Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents, Nanoscale, 9(4):1575-1579 (2017). PMID: 28067926

 

 

 

• Luo, X.,1 Wang, W.,1 Dorkin, J. R., Veiseh, O., Chang, P. H., Abutbul-Ionita, I., Danino, D., Langer, R., Anderson, D. G.,* Dong, Y.* Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo, Biomater. Sci, 5(1):38-40 (2017). PMID: 27921096

   

2016:

• Li, B.,1 Zhao, W.,1 Zhang, X.,1 Wang, J., Luo, X., Baker, S. D., Jordan, C. T., Dong, Y.* Design, synthesis and evaluation of anti-CD123 antibody drug conjugates, Bioorganic & Medicinal Chemistry, 24(22):5855-5860 (2016). PMID: 27687970

 

 

• Dong, Y., Wang, W., Veiseh, O., Appel, E. A., Xue, K., Webber, M. J., Tang, B., Yang, X. W., Weir, G., Langer, R., Anderson, D. G. Injectable and glucose-responsive hydrogels based on boronic acid–glucose complexation, Langmuir, 21(34):8743-8747 (2016). PMID: 27455412

 

 

 

• Wang, J., Li, B., Zhao, W., Zhang, X., Luo, X., Corkins, M. E., Cole, S. L., Wang, C., Xiao, Y., Bi, X., Pang, Y., McElroy, C. A., Bird, A. J., Dong, Y.* Two-photon near infrared (NIR-NIR) fluorescent turn-on probe toward cysteine (Cys) and its imaging applications, ACS Sens, 1(7):882-887 (2016).

   

• Li, B.,1 Luo, X.,1 Dong, Y.* Effects of chemically modified messenger RNA on protein expression, Bioconjugate Chemistry, 27(3):849-853 (2016). PMID:26906521

 

 

• Li, B.,1 Luo, X.,1 Deng, B., Giancola, D. W.,  McComb, D. W., Schmittgen, T. D., Dong, Y.* Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA, Scientific Reports, doi: 10.1038/srep22137 (2016). PMID: 26916931

 

 

• Yin, H., Song, C.-Q., Dorkin, R. J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M. F., Walsh, S., Bogorad, R. L., Gao, G., Weng, Z., Dong, Y., Kotelianski, V., Wolfe, S. A., Langer, R., Xue, W., Anderson, D. G. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34(3):328-333 (2016). PMID: 26829318

 

 

• Dong, Y.,1  Dorkin, R. J.,1 Wang, W., Chang, P. H., Webber, M. J., Tang, B. C., Yang, J., Abutbul-Ionita, I., Danino, D., DeRosa, F., Heartlein, M., Langer, R., Anderson, D.G. Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA delivery in Vivo, Nano Letters, 16(2):842-848 (2016). PMID: 26727632

 

 

2015:

• Li, B., Luo, X., Deng, B., Wang, J., McComb, D. W., Shi, Y., Gaensler, K. M. L., Tan, X., Dunn, A. L., Kerlin, B. A., Dong, Y.* An orthogonal array optimization of lipid-like nanoparticles for mRNA delivery in vivo, Nano Letters, 15(12):8099-8107 (2015). PMID: 26529392

 

 

• Khan, O. F., Zaia, E. W., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D. S., Barnes, C., Dahlman, J. E., Dong, Y., Pelet, J. M., Webber, M. J., Tsosie, J.,  Jacks, T., Langer, R., Anderson, D. G. Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature, Nano Letters, 15(5):3008-3016 (2015). PMID: 25789998

 

 

2014 and Prior:

• Dong, Y.;1 Eltoukhy, A. A.;1 Alabi, C. A.; Kohan, O. F.; Veiseh, O.; Dorkin, R. J.; Sirirungruang, S.; Yin, H.; Tang, B. C.; Pelet, J.; Chen, D.; Gu, Z.; Xue, Y.; Langer, R.; Anderson, D. G. Lipid like Nanomaterials for Simultaneous Gene Silencing and Expression in vivo, Advanced Healthcare Materials, 3 (9) 1392-1397 (2014). PMID: 24623658

• Dong, Y.; Love, K. T.; Dorkin, R. J.; Sirirungruang, S.; Zhang, Y.; Chen, D.; Bogorad, R., Yin, H., Chen, Y; Vegas, A.; Alabi, C. A.; Sahay, G., Olejnik, K. T.; Wang, W.; Shroeder, A.; Lytton-Jean, A. K. R.; Siegwart, D. J.; Akinc, A.; Barnes, C., Barros, S. A.; Carioto, M.; Fitzgerald, K.; Hettinger, J.; Kumar, V.; Novobrantseva, T. I.; Qin, J.; Querbers, W.; Kotelianski, V.; Langer, R.; Anderson, D. G. Lipopeptide Nanoparticles for Potent and Selective siRNA Delivery in Rodents and Nonhuman Primates, Proceedings of the National Academy of Sciences, 111 (11), 3955-3960 (2014). PMID: 24516150 (Highlighted by SciBX, 2014).

• Dahlman, J. E.; Barnes, C.; Khan, O. F.; Thiriot, A.; Jhunjunwala, S.; Shaw, T. E.; Xing, Y.; Sager, H. B.; Sahay, G.; Speciner, L.; Bader, A.; Bogorad, R. L.; Yin, H.; Racie, T.; Dong, Y.; Jiang, S.; Seedorf, D.; Dave, A.; Singh Sandhu, K.; Webber, M. J.; Novobrantseva, T.; Ruda, V. M.; Lytton-JeanAbigail, K. R.; Levins, C. G.; Kalish, B.; Mudge, D. K.; Perez, M.; Abezgauz, L.; Dutta, P.; Smith, L.; Charisse, K.; Kieran, M. W.; Fitzgerald, K.; Nahrendorf, M.; Danino, D.; Tuder, R. M.; von Andrian, U. H.; Akinc, A.; Panigrahy, D.; Schroeder, A.; Koteliansky, V.; Langer R.; Anderson, D. G. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight, Nature Nanotechnology, 9 (8), 648-655 (2014). PMID: 24813696

• Eltoukhy, A. A.; Chen, D.; Veiseh, O.; Pelet, J.; Yin, H.; Dong, Y.; Anderson, D. G. Nucleic Acid-Mediated Intracellular Protein Delivery by Lipid-like Nanoparticles, Biomaterials, 35 (24), 6454-6461 (2014). PMID: 24831975

• Gu, Z., Dang, T.T., Ma, M.M., Tang, B.C., Cheng, H., Jiang, S., Dong, Y., Zhang, Y., Anderson, D.G. Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery, ACS Nano, 7 (8), 6758-6766 (2013). PMID: 23834678

• Zhang, Y., Pelet, J.M., Heller, D.A., Dong, Y., Chen, D., Gu, Z., Joseph, B.J., Wallas, J., Anderson, D.G. Lipid-Modified Aminoglycoside Derivatives for in vivo siRNA Delivery, Advanced Materials, 33 (25) 4641–4645 (2013). PMID: 23813808

• Chen, D.; Love, K. T.; Chen, Y.; Eltoukhy, A. A.; Kastrup, C.; Dong, Y.; Whitehead, K. A.; Langer, R.; Anderson, D. G. Rapid Discovery of Potent siRNA-Lipid-Nanoparticles Enabled by Controlled Microfluidic Formulation, J. Am. Chem. Soc.,  134 (16), 6948–6951 (2012). PMID: 22475086

• Wang, L-T., Pan, S-L., Chen, T-H., Dong, Y., Lee, K. H., Teng, C-M. DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells, ChemBioChem.,  13 (11) 1663-1672 (2012). PMID: 22761044

• Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Yoon, K.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, E. Y.-H.; Lee, K. H. Antitumor Agents 289. Design, Synthesis, and In Vivo Anti-Breast Cancer Activity of 4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) Analogs with Improved Water Solubility, J. Nat. Prod.,  75 (3), 370–377 (2012). PMID: 22304236

• Lee, K. H.; Morris-Natschke, S. L.; Qian, K.; Dong, Y.; Yang, X.; Zhou, T.; Belding, E.; Wu, S. F.; Wada, K.; Akiyama, T. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman’s Herbal Foundation Canon, Journal of Traditional and Complementary Medicine, 2, 6-26 (2012). PMID: 24716110

• Dong, Y.; Morris-Natschke, S. L.; Lee, K. H. Biosynthesis, Total Syntheses, and Antitumor Activity of Tanshinones and their Analogs as Potential Therapeutic Agents, Nat. Prod. Rep, 28, 529-542 (2011). PMID: 21225077 (Selected and abstracted by ChemInform, 2011, 42, 27).

• Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 287. Substituted 4-amino-2H-pyran-2-one (APO) Analogs Reveal a New Scaffold from Neo-tanshinlactone with In Vitro Anticancer Activity, Bioorg. Med. Chem. Lett.,  21, 2341-2344 (2011). PMID: 21420855 (Selected and abstracted by ChemInform, 2011, 42, 34).

• Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 281. Design, Synthesis, and Biological Activity of Substituted 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) as Potent In Vitro Anticancer Agents, Bioorg. Med. Chem. Lett.,  21, 546-549 (2011). PMID: 21087859

• Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Yoon, K.; Wu, P. C.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, E. Y.-H.; Lee, K. H. Antitumor Agents 279. Structure-Activity Relationship and In Vivo Studies of Novel 2-(Furan-2-yl)naphthalen-1-ol (FNO) Analogs as Potent and Selective Anti-Breast Cancer Agents, Bioorg. Med. Chem. Lett.,  21, 52-57 (2011). PMID: 21147529

• Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 278. 4-Amino-2H-benzo[h]chromen-2-one Analogs (ABO) as Potent In Vitro Anticancer Agents, Bioorg. Med. Chem. Lett.,  20, 4085-4087 (2010). PMID: 20542429

• Chou, L.-C.; Tsai, M.-T.; Hsu, M.-H.; Wang, S.-H.; Way, T.-D.; Huang, C.-H.; Lin, H.-Y.; Qian, K.; Dong, Y.; Lee, K.-H.; Huang, L.-J.; Kuo, S.-C. Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents, J. Med. Chem., 53, 8047-8058 (2010). PMID: 20973552

• Dong, Y.; Shi, Q.; Pai, H-C.; Peng, C-Y.; Pan, S-L.; Teng, C-M.; Nakagawa-Goto,K. ; Yu, D.;Liu, Y-N.; Wu, P-C.; Bastow, K.; Morris-Natschke, S. L.;  Brossi, A.; Lang, J-Y.; Hsu, J. L.; Hung, M-C.; Lee, E. Y.-H. P. Lee, and Lee, K-H. Antitumor Agents 272. Structure–Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogs, J. Med. Chem., 53, 2299-2308 (2010). PMID: 20148565 (Highlighted by SciBX, February 25, 2010).

• Dong, Y.; Shi, Q.; Nakagawa-Goto,K. ; Wu, P. C.; Morris-Natschke, S. L.; Brossi, A.; Bastow, K.; Lee, K. H. Antitumor Agents 270. Novel Substituted 6-Phenyl-4H-furo[3,2-c]pyran-4-one Derivatives as Potent and Highly Selective Anti-Breast Cancer Agents, Bioorg. Med. Chem., 18, 803-808 (2010). PMID: 20034799 (Reported by NewsRX, Feb 22, 2010).

• Dong, Y.; Shi, Q.; Nakagawa-Goto,K. ; Wu, P. C.; Bastow, K.; Morris-Natschke, S. L.; Lee, K. H. Antitumor Agents 269. Non-Aromatic Ring-A Neo-tanshinlactone Analog, TNO, as a New Class of Potent Antitumor Agents, Bioorg. Med. Chem. Lett.,  19, 6289-6292 (2009). PMID: 19819136 (Selected and abstracted by ChemInform , 2010 , 41, 12-203).

• Dong, Y.; Shi, Q.; Liu, Y. -N.; Wang, X.; Bastow, K.F.; Lee, K.-H. Antitumor Agents 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents, J. Med. Chem.,  52, 3586-3590 (2009) (Highlighted by SciBX, May 21, 2009). PMID: 19425534

• Zhong, Y. W.; Dong, Y. ; Fang, K.; Izumi, K.; Xu, M. H.; Lin, G. Q. A Highly Efficient and Direct Approach for Synthesis of Enantiopure β-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes, J. Am. Chem. Soc., 127, 11956-11957 (2005). PMID: 16117531 (Highlighted by SYNFACTS , 2005, 3, 0331; Selected and abstracted by ChemInform , 2005, 37, 01-088).

*, corresponding author; 1, co-first author.

Patents and Inventions

• Dong, Y.; Li, B. Lipid-like nanoparticles (LLN) and uses thereof, U.S. Provisional Patent application No 62/164,891, The Ohio State University, 2015.
• Dong, Y.; Wang, W.; Appel, E.A.; Veiseh, O.; Webber, M.J.; Tang, B.C.; Xue, K.;Langer, R.; Anderson, D. G. Injectable hydrogels and Uses Thereof, U.S. Provisional Patent application No. 62/137,003, 2015.
• Dong, Y.; Dorkin, R. J.; Langer, R.; Anderson, D. G. Polymer-Lipid Brush and Uses Thereof, U.S. Provisional Patent application No. 62/036,492, 2014.
• Dong, Y.; Anderson, D. G. Lipid formulations for delivery of messenger RNA, U.S. Patent application No. 14/521,161, 2014.
• Dong, Y.; Love, K. T.; Chen, D.; Chen, Y; Zhang, Y.; Vegas, A.; Alabi, C. A.; Langer, R.; Anderson, D. G. Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof, U.S. Patent application No. 13662002, 2013. (Filed in over 30 countries and regions; Licensed by two companies)
• Dong, Y.; Eltoukhy, A.A., Alabi, C. A.; Yin, H.; Dorkin, R. J.; Chen, D.; Langer, R.; Anderson, D. G. 1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof, U.S. Patent application No. 14267530, 2014.
• Anderson, D. G.; Chen, D.; Dong, Y.; Veiseh, O.; Eltoukhy, A.A.; Yin, H.; Langer, R.; Method for Achieving Intracellular Protein Delivery Using Oligonucleotide Conjugation and Uses Thereof, MIT - 16539, 2013.
• Anderson, D. G.; Dahlman, J. E.; Dong, Y.; Khan, O. F.; Langer, R.; Degradable and Non-Degradable Dendrimer-Based Lipidoids and Uses Thereof, MIT - 16054, 2013.
• Zhang, Y.; Heller, D. A.; Pelet, J.; Dong, Y.; Synthetic Sugar-based Lipids and Uses Thereof, MIT - 15369, 2012.
• Shroeder, A.; Dong, Y.; Stark, W. J.; a Water Treatment Device, MIT - 14856, 2011.
• Lee, K. H.; Dong, Y.; Bastow, K. Nakagawa-Goto,K.; Lee, E. Y.-H. 4-Amino-2H-pyran-2-one Analogs as Anticancer Agents; Patent No. WO 2012061012, 2012.
• Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K. Substituted FNO (2-(Furan-2-yl) naphthalen-1-ol) Derivatives as Anti-cancer Agents; Patent No. WO 2010080414, 2011.
• Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K.; Wu. P. C. Substituted AFPO (6-aryl-4H-furo [3,2-c]pyran-4-one) Derivatives as Anti-cancer  Agents; Patent No. WO 2010080415, 2010.
• Lee, K. H.; Dong, Y.; Bastow, K. Nakagawa-Goto,K. Novel 4-amino-2H-benzo[h]chromen-2-one Analogs as Anti-Cancer agents; U.S. Provisional Patent application No. 61/317,983, 2010.
• Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K. Neo-tanshinlactone Analogs as Potent and Selective Anti-breast Cancer Agents; U.S. Provisional Patent application No. 61/243,731, 2009.
• Xu, M. H.; Lin, G. Q.; Zhong, Y. W.; Dong, Y. Process for Preparation of Chiral  Amino Alcohols and Derivatives via Cross-coupling Reaction.  Faming Zhuanli Shenqing Gongkai Shuomingshu (China Patent), 2005, CN1709865.